Kinetic analysis of correct nucleotide insertion by a Y-family DNA polymerase reveals conformational changes both prior to and following phosphodiester bond formation as detected by tryptophan fluorescence.

Beckman JW, Wang Q, Guengerich FP
J Biol Chem. 2008 283 (52): 36711-23

PMID: 18984592 · PMCID: PMC2605995 · DOI:10.1074/jbc.M806785200

MeSH Terms (15)

Catalysis DNA DNA-Directed DNA Polymerase Kinetics Molecular Conformation Mutagenesis Mutation Nucleotides Phosphates Plasmids Protein Conformation Spectrometry, Fluorescence Sulfolobus solfataricus Time Factors Tryptophan

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