Posttranslational regulation of surfactant protein B expression.

Guttentag S
Semin Perinatol. 2008 32 (5): 367-70

PMID: 18929160 · PMCID: PMC2586979 · DOI:10.1053/j.semperi.2008.08.003

Although a minor constituent by weight, surfactant protein B (SP-B) plays a major role in surfactant function. It is the unique structure of SP-B that promotes permeabilization, cross-linking, mixing, and fusion of phospholipids, facilitating the proper structure and function of pulmonary surfactant as well as contributing to the formation of lamellar bodies. SP-B production is a complex process within alveolar type 2 cells and is under hormonal and developmental control. Understanding the posttranslational events in the maturation of SP-B may provide new insight into the process of lamellar body formation and into the pathophysiology of pulmonary disorders associated with surfactant abnormalities.

MeSH Terms (11)

Dimerization Gene Expression Regulation Glycosylation Humans Peptide Hydrolases Protein Folding Protein Precursors Protein Processing, Post-Translational Proteolipids Pulmonary Alveoli Pulmonary Surfactant-Associated Protein B

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