Cell sorting in three dimensions: topology, fluctuations, and fluidlike instabilities.

Hutson MS, Brodland GW, Yang J, Viens D
Phys Rev Lett. 2008 101 (14): 148105

PMID: 18851581 · DOI:10.1103/PhysRevLett.101.148105

Previous 2D and 3D models concluded that cell sorting requires cytoskeletal fluctuations and is stalled by high tension at heterotypic interfaces. New deterministic and stochastic models show that this is not true in 3D. Sorting in 3D involves both topological untangling and domain coalescence. Coalescence requires fluctuations and low tension, but untangling does not. It occurs by a Plateau-Rayleigh instability of cell threads-deterministically driven by high tension. At high minority-cell fractions, untangling dominates and significant partial sorting can occur without fluctuations.

MeSH Terms (7)

Algorithms Cell Aggregation Cell Separation Computer Simulation Imaging, Three-Dimensional Models, Biological Stochastic Processes

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