Amitriptyline activates cardiac ryanodine channels and causes spontaneous sarcoplasmic reticulum calcium release.

Chopra N, Laver D, Davies SS, Knollmann BC
Mol Pharmacol. 2009 75 (1): 183-95

PMID: 18845675 · PMCID: PMC2685059 · DOI:10.1124/mol.108.051490

MeSH Terms (17)

Amitriptyline Animals Antidepressive Agents, Tricyclic Calcium Cells, Cultured Dose-Response Relationship, Drug Female Fluorescent Dyes Fura-2 Heart Ventricles Male Mice Mice, Inbred C57BL Myocytes, Cardiac Ryanodine Receptor Calcium Release Channel Sarcoplasmic Reticulum Time Factors

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