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Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats.

Jones CK, Brady AE, Davis AA, Xiang Z, Bubser M, Tantawy MN, Kane AS, Bridges TM, Kennedy JP, Bradley SR, Peterson TE, Ansari MS, Baldwin RM, Kessler RM, Deutch AY, Lah JJ, Levey AI, Lindsley CW, Conn PJ
J Neurosci. 2008 28 (41): 10422-33

PMID: 18842902 · PMCID: PMC2577155 · DOI:10.1523/JNEUROSCI.1850-08.2008

MeSH Terms (25)

Allosteric Site Amyloid Amyloid beta-Protein Precursor Animals Antipsychotic Agents Benzimidazoles CHO Cells Cricetinae Cricetulus Dose-Response Relationship, Drug Electric Conductivity Hippocampus In Vitro Techniques Male Patch-Clamp Techniques Piperidines Protein Processing, Post-Translational Pyramidal Cells Rats Rats, Sprague-Dawley Receptor, Muscarinic M1 Receptors, Dopamine D2 Receptors, N-Methyl-D-Aspartate Synaptic Transmission Transfection

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