Discovery of an orally bioavailable small molecule inhibitor of prosurvival B-cell lymphoma 2 proteins.

Park CM, Bruncko M, Adickes J, Bauch J, Ding H, Kunzer A, Marsh KC, Nimmer P, Shoemaker AR, Song X, Tahir SK, Tse C, Wang X, Wendt MD, Yang X, Zhang H, Fesik SW, Rosenberg SH, Elmore SW
J Med Chem. 2008 51 (21): 6902-15

PMID: 18841882 · DOI:10.1021/jm800669s

MeSH Terms (12)

Administration, Oral Animals Cell Line Cell Survival Drug Evaluation, Preclinical Humans Mice Molecular Structure Proto-Oncogene Proteins c-bcl-2 Structure-Activity Relationship Sulfonamides Xenograft Model Antitumor Assays

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