Synthesis and SAR of analogues of the M1 allosteric agonist TBPB. Part I: Exploration of alternative benzyl and privileged structure moieties.

Bridges TM, Brady AE, Kennedy JP, Daniels RN, Miller NR, Kim K, Breininger ML, Gentry PR, Brogan JT, Jones CK, Conn PJ, Lindsley CW
Bioorg Med Chem Lett. 2008 18 (20): 5439-42

PMID: 18805692 · PMCID: PMC3177598 · DOI:10.1016/j.bmcl.2008.09.023

MeSH Terms (16)

Acetylcholine Allosteric Regulation Allosteric Site Benzimidazoles Binding Sites Chemistry, Pharmaceutical Dose-Response Relationship, Drug Drug Design Humans Inhibitory Concentration 50 Ligands Models, Chemical Piperidines Receptor, Muscarinic M1 Structure-Activity Relationship Time Factors

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