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The effects of growth hormone and insulin-like growth factor-1 on the aging cardiovascular system and its progenitor cells.

Devin JK, Young PP
Curr Opin Investig Drugs. 2008 9 (9): 983-92

PMID: 18729005

Aging is a major risk factor for the development of cardiovascular disease. Aging is also associated with a decline in the growth hormone (GH) and insulin-like growth factor-1 (IGF-1) axis. This axis impacts endothelial and vascular smooth muscle cell biology, as well as cardiac function. The number of endothelial progenitor cells (EPCs) also decreases with age and is emerging as a surrogate measurement of vascular senescence. Studies suggest that EPCs impact vascular health by modulating vascular repair and function. Current evidence demonstrates that EPC number and function is restored with a GH-mediated increase in serum IGF-1. Modulation of the GH and IGF-1 system may therefore provide a useful therapy in the prevention of age-associated changes in the cardiovascular system and in future regenerative cell-based therapies.

MeSH Terms (17)

Aged Aging Animals Cardiovascular Diseases Cardiovascular Physiological Phenomena Clinical Trials as Topic Growth Hormone Hormone Replacement Therapy Human Growth Hormone Humans Indoles Insulin-Like Growth Factor I Myocytes, Smooth Muscle Risk Spiro Compounds Stem Cells Stem Cell Transplantation

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