Oxidative stress plays a critical role in inactivating mutant BRAF by geldanamycin derivatives.

Fukuyo Y, Inoue M, Nakajima T, Higashikubo R, Horikoshi NT, Hunt C, Usheva A, Freeman ML, Horikoshi N
Cancer Res. 2008 68 (15): 6324-30

PMID: 18676857 · PMCID: PMC2693332 · DOI:10.1158/0008-5472.CAN-07-6602

MeSH Terms (12)

Acetylcysteine Antibiotics, Antineoplastic Benzoquinones Cell Line, Tumor Enzyme Activation HSP90 Heat-Shock Proteins Humans Lactams, Macrocyclic Mitogen-Activated Protein Kinases Mutation Oxidative Stress Proto-Oncogene Proteins B-raf

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