Defective activity of recombinant cytochromes P450 3A4.2 and 3A4.16 in oxidation of midazolam, nifedipine, and testosterone.

Miyazaki M, Nakamura K, Fujita Y, Guengerich FP, Horiuchi R, Yamamoto K
Drug Metab Dispos. 2008 36 (11): 2287-91

PMID: 18669585 · DOI:10.1124/dmd.108.021816

MeSH Terms (13)

Alleles Catalysis Cytochrome P-450 CYP3A Enzyme Activation Humans Isoenzymes Microsomes, Liver Midazolam Nifedipine Oxidation-Reduction Recombinant Proteins Substrate Specificity Testosterone

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