Enhancement of the CD8+ T cell response to a subdominant epitope of respiratory syncytial virus by deletion of an immunodominant epitope.

Mok H, Lee S, Wright DW, Crowe JE
Vaccine. 2008 26 (37): 4775-82

PMID: 18662734 · PMCID: PMC2561208 · DOI:10.1016/j.vaccine.2008.07.012

Cytotoxic T lymphocytes (CTLs) are critical for the control of respiratory syncytial virus infection (RSV) in humans and mice. Recently, we identified a new H-2K(d)-restricted subdominant epitope in the respiratory syncytial virus M2 protein. In this study, we investigated if modification of anchor residues at positions 2 and 9 in the dominant M2(82-90) epitope in the M2 protein would alter the CTL epitope dominance hierarchy following immunization with plasmid DNA encoding M2 proteins. We showed that immunogenicity of the subdominant epitope M2(127-135) was enhanced when the anchor residues of the dominant epitope were mutated, suggesting that the immunodominant epitope induces a suppression of response to the subdominant epitope.

MeSH Terms (13)

Amino Acid Substitution Animals CD8-Positive T-Lymphocytes Epitopes, T-Lymphocyte Female Immunodominant Epitopes Mice Mice, Inbred BALB C Plasmids Respiratory Syncytial Viruses Respiratory Syncytial Virus Vaccines Vaccines, DNA Viral Proteins

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