Human topoisomerase IIalpha uses a two-metal-ion mechanism for DNA cleavage.

Deweese JE, Burgin AB, Osheroff N
Nucleic Acids Res. 2008 36 (15): 4883-93

PMID: 18653531 · PMCID: PMC2528187 · DOI:10.1093/nar/gkn466

MeSH Terms (10)

Antigens, Neoplasm Cations, Divalent DNA DNA-Binding Proteins DNA Cleavage DNA Topoisomerases, Type II Humans Metals Models, Chemical Phosphates

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