Replacement of native adenovirus receptor-binding sites with a new attachment moiety diminishes hepatic tropism and enhances bioavailability in mice.

Schagen FH, Graat HC, Carette JE, Vellinga J, van Geer MA, Hoeben RC, Dermody TS, van Beusechem VW
Hum Gene Ther. 2008 19 (8): 783-94

PMID: 18627267 · PMCID: PMC2736798 · DOI:10.1089/hum.2007.133

MeSH Terms (19)

Adenoviruses, Human Animals Antigens, Viral Binding Sites Biological Availability Capsid Proteins Cell Line, Tumor Erythrocytes Female Gene Targeting Genetic Therapy Genetic Vectors Hepatocytes Humans Mice Mice, Inbred C57BL Rats Transduction, Genetic Viral Tail Proteins

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