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Integrating host genomics with surveillance for invasive bacterial diseases.

Crawford DC, Zimmer SM, Morin CA, Messonnier NE, Lynfield R, Yi Q, Shephard C, Wong M, Rieder MJ, Livingston RJ, Nickerson DA, Whitney CG, Lingappa J
Emerg Infect Dis. 2008 14 (7): 1138-40

PMID: 18598642 · PMCID: PMC2600343 · DOI:10.3201/eid1407.071287

We tested the feasibility of linking Active Bacterial Core surveillance, a prospective, population-based surveillance system for invasive bacterial disease, to a newborn dried blood spot (nDBS) repository. Using nDBS specimens, we resequenced CD46, putative host gene receptor for Neisseria meningitidis, and identified variants associated with susceptibility to this disease.

MeSH Terms (13)

Case-Control Studies Child, Preschool Feasibility Studies Genetic Predisposition to Disease Humans Infant Infant, Newborn Membrane Cofactor Protein Meningitis, Bacterial Neonatal Screening Polymorphism, Single Nucleotide Population Surveillance Retrospective Studies

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