ATR: an essential regulator of genome integrity.

Cimprich KA, Cortez D
Nat Rev Mol Cell Biol. 2008 9 (8): 616-27

PMID: 18594563 · PMCID: PMC2663384 · DOI:10.1038/nrm2450

Genome maintenance is a constant concern for cells, and a coordinated response to DNA damage is required to maintain cellular viability and prevent disease. The ataxia-telangiectasia mutated (ATM) and ATM and RAD3-related (ATR) protein kinases act as master regulators of the DNA-damage response by signalling to control cell-cycle transitions, DNA replication, DNA repair and apoptosis. Recent studies have provided new insights into the mechanisms that control ATR activation, have helped to explain the overlapping but non-redundant activities of ATR and ATM in DNA-damage signalling, and have clarified the crucial functions of ATR in maintaining genome integrity.

MeSH Terms (13)

Animals Ataxia Telangiectasia Mutated Proteins Carrier Proteins Cell Cycle Proteins DNA-Binding Proteins DNA Damage Genomic Instability Humans Models, Biological Nuclear Proteins Protein-Serine-Threonine Kinases Protein Processing, Post-Translational Signal Transduction

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