Enzymatic ligation creates discrete multinanoparticle building blocks for self-assembly.

Claridge SA, Mastroianni AJ, Au YB, Liang HW, Micheel CM, Fr├ęchet JM, Alivisatos AP
J Am Chem Soc. 2008 130 (29): 9598-605

PMID: 18588300 · DOI:10.1021/ja8026746

Enzymatic ligation of discrete nanoparticle-DNA conjugates creates nanoparticle dimer and trimer structures in which the nanoparticles are linked by single-stranded DNA, rather than by double-stranded DNA as in previous experiments. Ligation was verified by agarose gel and small-angle X-ray scattering. This capability was utilized in two ways: first, to create a new class of multiparticle building blocks for nanoscale self-assembly and, second, to develop a system that can amplify a population of discrete nanoparticle assemblies.

MeSH Terms (11)

Chromatography, High Pressure Liquid Chromatography, Ion Exchange DNA, Single-Stranded DNA Adducts DNA Ligases Electrophoresis, Polyacrylamide Gel Gold Metal Nanoparticles Models, Molecular Scattering, Small Angle X-Ray Diffraction

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