A bridging water anchors the tethered 5-(3-aminopropyl)-2'-deoxyuridine amine in the DNA major groove proximate to the N+2 C.G base pair: implications for formation of interstrand 5'-GNC-3' cross-links by nitrogen mustards.

Wang F, Li F, Ganguly M, Marky LA, Gold B, Egli M, Stone MP
Biochemistry. 2008 47 (27): 7147-57

PMID: 18549246 · PMCID: PMC2730145 · DOI:10.1021/bi800375m

MeSH Terms (17)

Base Pairing Base Sequence Calorimetry Cations Cross-Linking Reagents Crystallization Deoxyguanine Nucleotides Deoxyuridine DNA Molecular Sequence Data Nitrogen Mustard Compounds Nucleic Acid Conformation Nucleic Acid Heteroduplexes Static Electricity Thermodynamics Transition Temperature Water

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