The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis.

Neubert K, Meister S, Moser K, Weisel F, Maseda D, Amann K, Wiethe C, Winkler TH, Kalden JR, Manz RA, Voll RE
Nat Med. 2008 14 (7): 748-55

PMID: 18542049 · DOI:10.1038/nm1763

MeSH Terms (16)

Animals Boronic Acids Bortezomib Lupus Erythematosus, Systemic Mice Mice, Inbred BALB C Mice, Inbred MRL lpr Mice, Inbred NZB Models, Immunological Nephritis Ovalbumin Plasma Cells Protease Inhibitors Proteasome Inhibitors Pyrazines Time Factors

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