Injectable biodegradable polyurethane scaffolds with release of platelet-derived growth factor for tissue repair and regeneration.

Hafeman AE, Li B, Yoshii T, Zienkiewicz K, Davidson JM, Guelcher SA
Pharm Res. 2008 25 (10): 2387-99

PMID: 18516665 · PMCID: PMC3842433 · DOI:10.1007/s11095-008-9618-z

PURPOSE - The purpose of this work was to investigate the effects of triisocyanate composition on the biological and mechanical properties of biodegradable, injectable polyurethane scaffolds for bone and soft tissue engineering.

METHODS - Scaffolds were synthesized using reactive liquid molding techniques, and were characterized in vivo in a rat subcutaneous model. Porosity, dynamic mechanical properties, degradation rate, and release of growth factors were also measured.

RESULTS - Polyurethane scaffolds were elastomers with tunable damping properties and degradation rates, and they supported cellular infiltration and generation of new tissue. The scaffolds showed a two-stage release profile of platelet-derived growth factor, characterized by a 75% burst release within the first 24 h and slower release thereafter.

CONCLUSIONS - Biodegradable polyurethanes synthesized from triisocyanates exhibited tunable and superior mechanical properties compared to materials synthesized from lysine diisocyanates. Due to their injectability, biocompatibility, tunable degradation, and potential for release of growth factors, these materials are potentially promising therapies for tissue engineering.

MeSH Terms (24)

Absorbable Implants Animals Biomechanical Phenomena Bone Regeneration Cell Line Cross-Linking Reagents Drug Carriers Elasticity Hydrolysis Injections, Subcutaneous Isocyanates Kinetics Male Mice Osteoblasts Platelet-Derived Growth Factor Polyurethanes Porosity Rats Rats, Sprague-Dawley Solubility Temperature Tissue Engineering Tissue Scaffolds

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