Changing patterns of medication use in patients with rheumatoid arthritis in a Medicaid population.

Grijalva CG, Chung CP, Stein CM, Mitchel EF, Griffin MR
Rheumatology (Oxford). 2008 47 (7): 1061-4

PMID: 18499716 · PMCID: PMC4819998 · DOI:10.1093/rheumatology/ken193

OBJECTIVE - To examine changes in patterns of medication utilization in patients with RA.

METHODS - Data from Tennessee Medicaid (TennCare) databases (1995-2004) were used to identify adults with both a diagnosis of RA and at least one DMARD prescription each year. Annual age-specific utilization of DMARDs, glucocorticoids, NSAIDs and narcotics was measured on the last day of each year to determine the point prevalence of use of these agents.

RESULTS - Records from 23 342 patients with treated RA were analysed. Most patients were females (78%) and white (74%). The median age was 57 yrs (interquartile range: 48-65). The proportion of patients who had a current DMARD prescription on the index date increased from 62% in 1995 to 71% in 2004 (P < 0.001). MTX was the most commonly used DMARD. By the end of 2004, 22% of patients had a current prescription for a biologic, and etanercept represented 51% of all biologic therapies. During the study period, the overall utilization of glucocorticoids decreased from 46% to 38% (P < 0.001), whereas NSAID utilization increased from 33% to 38% (P < 0.001), and use of narcotics increased from 38% to 55% (P < 0.001). A secondary analysis that identified RA patients based on diagnosis codes alone, showed similar patterns, but lower DMARD utilization which increased from 33% to 52% overall and from 0% to 16% for biologics.

CONCLUSIONS - The utilization of DMARDs increased in TennCare patients with RA, and by 2004, use of biologics was substantial. Although glucocorticoid utilization decreased, use of both NSAIDs and narcotics increased.

MeSH Terms (18)

Adolescent Adult Aged Analgesics, Opioid Anti-Inflammatory Agents, Non-Steroidal Antirheumatic Agents Arthritis, Rheumatoid Drug Therapy, Combination Drug Utilization Female Glucocorticoids Humans Immunologic Factors Male Medicaid Middle Aged Tennessee United States

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