Electrophilic cyclopentenone neuroprostanes are anti-inflammatory mediators formed from the peroxidation of the omega-3 polyunsaturated fatty acid docosahexaenoic acid.

Musiek ES, Brooks JD, Joo M, Brunoldi E, Porta A, Zanoni G, Vidari G, Blackwell TS, Montine TJ, Milne GL, McLaughlin B, Morrow JD
J Biol Chem. 2008 283 (29): 19927-35

PMID: 18490445 · PMCID: PMC2459280 · DOI:10.1074/jbc.M803625200

MeSH Terms (18)

Alzheimer Disease Animals Cell Line Cyclooxygenase 2 Cyclopentanes Docosahexaenoic Acids Electrons Humans I-kappa B Kinase Inflammation Lipid Peroxidation Lipopolysaccharides Macrophages Mice Molecular Structure NF-kappa B Nitric Oxide Synthase Type II Signal Transduction

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