Kindlin-2 controls bidirectional signaling of integrins.

Montanez E, Ussar S, Schifferer M, Bösl M, Zent R, Moser M, Fässler R
Genes Dev. 2008 22 (10): 1325-30

PMID: 18483218 · PMCID: PMC2377186 · DOI:10.1101/gad.469408

Control of integrin activation is required for cell adhesion and ligand-induced signaling. Here we report that loss of the focal adhesion protein Kindlin-2 in mice results in peri-implantation lethality caused by severe detachment of the endoderm and epiblast from the basement membrane. We found that Kindlin-2-deficient cells were unable to activate their integrins and that Kindlin-2 is required for talin-induced integrin activation. Furthermore, we demonstrate that Kindlin-2 is required for integrin outside-in signaling to enable firm adhesion and spreading. Our findings provide evidence that Kindlin-2 is a novel and essential element of bidirectional integrin signaling.

MeSH Terms (19)

Actins Animals Blastocyst Cell Adhesion CHO Cells Cricetinae Cricetulus Cytoskeletal Proteins Embryo, Mammalian Embryo Loss Endoderm Integrins Mice Mice, Knockout Muscle Proteins Polymers Protein Binding Signal Transduction Talin

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