Hedgehog coordination of postnatal osteoclast and osteoblast activities.

Mundy GR, Yang X
Dev Cell. 2008 14 (5): 637-8

PMID: 18477444 · DOI:10.1016/j.devcel.2008.04.010

The Hedgehog (Hh) pathway is important for skeletal patterning and morphogenesis during embryonic development. Papers by Ohba et al. and Mak et al. in this edition of Developmental Cell suggest that Hh signaling may exert delicate control over the activities of osteoclasts and osteoblasts, the cell types primarily responsible for bone resorption and formation.

MeSH Terms (13)

Animals Animals, Newborn Humans Mice Organ Size Osteoblasts Osteoclasts Osteogenesis Parathyroid Hormone-Related Protein Patched Receptors RANK Ligand Receptors, Cell Surface Signal Transduction

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