Invariant natural killer T cells trigger adaptive lymphocytes to churn up bile.

Joyce S, Van Kaer L
Cell Host Microbe. 2008 3 (5): 275-7

PMID: 18474352 · DOI:10.1016/j.chom.2008.04.007

How innate immune response causes autoimmunity has remained an enigma. In this issue of Cell Host & Microbe, Mattner et al. demonstrate that invariant natural killer T cells activated by the mucosal commensal Novosphingobium aromaticivorans precipitate chronic T cell-mediated autoimmunity against small bile ducts that mirrors human primary biliary cirrhosis. These findings provide a mechanistic understanding of the role of innate immunity toward a microbe in the development of autoimmunity.

MeSH Terms (6)

Animals Autoimmunity Humans Killer Cells, Natural Liver Cirrhosis, Biliary T-Lymphocyte Subsets

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