Palmitate impairs and eicosapentaenoate restores insulin secretion through regulation of SREBP-1c in pancreatic islets.

Kato T, Shimano H, Yamamoto T, Ishikawa M, Kumadaki S, Matsuzaka T, Nakagawa Y, Yahagi N, Nakakuki M, Hasty AH, Takeuchi Y, Kobayashi K, Takahashi A, Yatoh S, Suzuki H, Sone H, Yamada N
Diabetes. 2008 57 (9): 2382-92

PMID: 18458149 · PMCID: PMC2518489 · DOI:10.2337/db06-1806

MeSH Terms (25)

Adenoviridae Animals Eicosapentaenoic Acid Gene Expression Gene Silencing Insulin Insulin Receptor Substrate Proteins Insulin Secretion Intracellular Signaling Peptides and Proteins Ion Channels Islets of Langerhans Lipogenesis Male Mice Mice, Inbred C57BL Mice, Mutant Strains Mitochondrial Proteins Organ Culture Techniques Palmitates Phosphoproteins Proto-Oncogene Proteins c-akt RNA, Messenger Signal Transduction Sterol Regulatory Element Binding Protein 1 Uncoupling Protein 2

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