Genetic basis for adverse events after smallpox vaccination.

Reif DM, McKinney BA, Motsinger AA, Chanock SJ, Edwards KM, Rock MT, Moore JH, Crowe JE
J Infect Dis. 2008 198 (1): 16-22

PMID: 18454680 · PMCID: PMC2746083 · DOI:10.1086/588670

Identifying genetic factors associated with the development of adverse events might allow screening before vaccinia virus administration. Two independent clinical trials of the smallpox vaccine (Aventis Pasteur) were conducted in healthy, vaccinia virus-naive adult volunteers. Volunteers were assessed repeatedly for local and systemic adverse events (AEs) associated with the receipt of vaccine and underwent genotyping for 1,442 singlenucleotide polymorphisms (SNPs). In the first study, 36 SNPs in 26 genes were associated with systemic AEs (P

MeSH Terms (12)

Adult Female Genetic Predisposition to Disease Genotype Humans Interferon Regulatory Factor-1 Interleukin-4 Male Methylenetetrahydrofolate Reductase (NADPH2) Polymorphism, Single Nucleotide Smallpox Vaccine Vaccination

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