Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction.

Adler DH, Cogan JD, Phillips JA, Schnetz-Boutaud N, Milne GL, Iverson T, Stein JA, Brenner DA, Morrow JD, Boutaud O, Oates JA
J Clin Invest. 2008 118 (6): 2121-31

PMID: 18451993 · PMCID: PMC2350426 · DOI:10.1172/JCI30473

MeSH Terms (16)

Arachidonic Acid Blood Platelets Calcium Eicosanoids Group IV Phospholipases A2 Heterozygote Humans Intestine, Small Ionophores Male Middle Aged Models, Biological Prostaglandin-Endoperoxide Synthases Prostaglandin D2 Thromboxane A2 Ulcer

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