Development of oxidative stress by cytochrome P450 induction in rodents is selective for barbiturates and related to loss of pyridine nucleotide-dependent protective systems.

Dostalek M, Hardy KD, Milne GL, Morrow JD, Chen C, Gonzalez FJ, Gu J, Ding X, Johnson DA, Johnson JA, Martin MV, Guengerich FP
J Biol Chem. 2008 283 (25): 17147-57

PMID: 18442974 · PMCID: PMC2427356 · DOI:10.1074/jbc.M802447200

MeSH Terms (15)

Animals Barbiturates Cytochrome P-450 Enzyme System Glutathione Peroxidase Glutathione Reductase Liver Mice Mice, Transgenic Microsomes, Liver Nicotinamide N-Methyltransferase Nucleotides Oxidative Stress Pyridines Rats Reactive Oxygen Species

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