Substituents on etoposide that interact with human topoisomerase IIalpha in the binary enzyme-drug complex: contributions to etoposide binding and activity.

Bender RP, Jablonksy MJ, Shadid M, Romaine I, Dunlap N, Anklin C, Graves DE, Osheroff N
Biochemistry. 2008 47 (15): 4501-9

PMID: 18355043 · PMCID: PMC2737519 · DOI:10.1021/bi702019z

MeSH Terms (10)

Antigens, Neoplasm Antineoplastic Agents, Phytogenic DNA DNA-Binding Proteins DNA Topoisomerases, Type II Drug Design Etoposide Humans Podophyllotoxin Protein Binding

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