Low oxygen stimulates the immune system.

Maltzman JS, Haase VH
Kidney Int. 2008 73 (7): 797-9

PMID: 18340350 · PMCID: PMC3791324 · DOI:10.1038/ki.2008.15

Changes in tissue oxygen levels trigger molecular signaling pathways that regulate cellular proliferation and differentiation in multiple cell types. The functional role of oxygen signaling in the immune system is not well understood. Rama and colleagues demonstrate that hypoxia induces dendritic-cell maturation; thus they provide a novel mechanistic link between hypoxia/ischemia and the activation of the immune system in the kidney.

MeSH Terms (6)

Basic Helix-Loop-Helix Transcription Factors Cell Hypoxia Dendritic Cells Hypoxia-Inducible Factor 1 Immune System Kidney Diseases

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