Suppression of PTEN function increases breast cancer chemotherapeutic drug resistance while conferring sensitivity to mTOR inhibitors.

Steelman LS, Navolanic PM, Sokolosky ML, Taylor JR, Lehmann BD, Chappell WH, Abrams SL, Wong EW, Stadelman KM, Terrian DM, Leslie NR, Martelli AM, Stivala F, Libra M, Franklin RA, McCubrey JA
Oncogene. 2008 27 (29): 4086-95

PMID: 18332865 · PMCID: PMC3836277 · DOI:10.1038/onc.2008.49

MeSH Terms (19)

Amino Acid Substitution Antibiotics, Antineoplastic Breast Neoplasms Cell Line, Tumor Doxorubicin Drug Resistance, Neoplasm Drug Synergism Female Gene Expression Humans Mutation, Missense Protein Kinases Proto-Oncogene Proteins c-akt PTEN Phosphohydrolase Ribosomal Protein S6 Kinases, 70-kDa Signal Transduction Sirolimus TOR Serine-Threonine Kinases Transfection

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