Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice.

Martínez-Chantar ML, Vázquez-Chantada M, Ariz U, Martínez N, Varela M, Luka Z, Capdevila A, Rodríguez J, Aransay AM, Matthiesen R, Yang H, Calvisi DF, Esteller M, Fraga M, Lu SC, Wagner C, Mato JM
Hepatology. 2008 47 (4): 1191-9

PMID: 18318442 · PMCID: PMC2405897 · DOI:10.1002/hep.22159

MeSH Terms (22)

Animals Carcinoma, Hepatocellular DNA Methylation Epigenesis, Genetic Fatty Liver Glycine N-Methyltransferase Histones Janus Kinases Liver Cirrhosis Liver Neoplasms Male Methionine Mice Mice, Knockout Promoter Regions, Genetic ras Proteins S-Adenosylmethionine Signal Transduction STAT Transcription Factors Suppressor of Cytokine Signaling Proteins Transaminases Tumor Suppressor Proteins

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