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Primary hepatic myxoid leiomyosarcoma: a case report and review of the literature.

Tsiatis AC, Atkinson JB, Wright JK, Cates JM
Ultrastruct Pathol. 2008 32 (1): 25-8

PMID: 18300035 · DOI:10.1080/01913120701696122

Sarcomas of the adult liver are unusual neoplasms, and can sometimes pose a difficult differential diagnosis. The authors report a myxoid spindle cell tumor arising in the liver of a 26-year-old woman. Histopathologic, immunohistochemical, and ultrastructural analysis demonstrated features of smooth muscle differentiation. Neoplastic nuclei were positive for estrogen receptor-beta and androgen receptor, but not estrogen receptor-alpha or progesterone receptor. Based on the large size of the tumor and the presence of conspicuous mitotic activity, the diagnosis of myxoid leiomyosarcoma was made. This case represents the third documented example of this tumor in the liver. The differential diagnosis in relation to this particular site of origin is discussed.

MeSH Terms (11)

Actins Adult Biomarkers, Tumor Diagnosis, Differential Female Fibrosarcoma Hepatectomy Humans Leiomyosarcoma Liver Neoplasms Neoplasms, Germ Cell and Embryonal

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