Hepatic glucose sensing: does flux matter?

Shiota M, Magnuson MA
J Clin Invest. 2008 118 (3): 841-4

PMID: 18292804 · PMCID: PMC2248806 · DOI:10.1172/JCI35137

In this issue of the JCI, Denechaud et al. report studies investigating the role of the liver X receptors (LXRs) LXRalpha and LXRbeta in carbohydrate sensing by the liver (see the related article beginning on page 956). The results of this study, which utilized LXRalpha/beta double-KO mice, strongly contradict a recent Nature report that proposed that LXRalpha/beta sense glucose independent of metabolic flux. The reported findings further support a key role for the carbohydrate-responsive element-binding protein (ChREBP) in the regulation of lipogenic genes by glucose and dietary carbohydrates.

MeSH Terms (13)

Animals DNA-Binding Proteins Gene Expression Regulation Glucose Lipogenesis Liver Liver X Receptors Mice Nuclear Proteins Orphan Nuclear Receptors Receptors, Cytoplasmic and Nuclear Sterol Regulatory Element Binding Protein 1 Transcription Factors

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