Immunodominance of the VH1-46 antibody gene segment in the primary repertoire of human rotavirus-specific B cells is reduced in the memory compartment through somatic mutation of nondominant clones.

Tian C, Luskin GK, Dischert KM, Higginbotham JN, Shepherd BE, Crowe JE
J Immunol. 2008 180 (5): 3279-88

PMID: 18292552 · DOI:10.4049/jimmunol.180.5.3279

MeSH Terms (17)

Adult Antibodies, Viral Antigens, Viral B-Lymphocyte Subsets Capsid Proteins Clone Cells Epitopes, B-Lymphocyte Humans Immunodominant Epitopes Immunoglobulin Class Switching Immunoglobulin Heavy Chains Immunoglobulin Variable Region Immunologic Memory Middle Aged Resting Phase, Cell Cycle Rotavirus Somatic Hypermutation, Immunoglobulin

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