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Drug-induced activation of dopamine D(1) receptor signaling and inhibition of class I/II histone deacetylase induce chromatin remodeling in reward circuitry and modulate cocaine-related behaviors.

Schroeder FA, Penta KL, Matevossian A, Jones SR, Konradi C, Tapper AR, Akbarian S
Neuropsychopharmacology. 2008 33 (12): 2981-92

PMID: 18288092 · PMCID: PMC2746694 · DOI:10.1038/npp.2008.15

MeSH Terms (25)

Acetylation Animals Brain Brain-Derived Neurotrophic Factor Brain Chemistry Chromatin Assembly and Disassembly Cocaine Cocaine-Related Disorders Disease Models, Animal Dopamine Dopamine Agonists Dopamine Uptake Inhibitors Enzyme Inhibitors Histone Deacetylase 1 Histone Deacetylase Inhibitors Histone Deacetylases Histones Male Mice Mice, Inbred C57BL Receptors, Dopamine D1 Reward Signal Transduction Synaptic Transmission Tyrosine 3-Monooxygenase

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