6-Ethynylthieno[3,2-d]- and 6-ethynylthieno[2,3-d]pyrimidin-4-anilines as tunable covalent modifiers of ErbB kinases.

Wood ER, Shewchuk LM, Ellis B, Brignola P, Brashear RL, Caferro TR, Dickerson SH, Dickson HD, Donaldson KH, Gaul M, Griffin RJ, Hassell AM, Keith B, Mullin R, Petrov KG, Reno MJ, Rusnak DW, Tadepalli SM, Ulrich JC, Wagner CD, Vanderwall DE, Waterson AG, Williams JD, White WL, Uehling DE
Proc Natl Acad Sci U S A. 2008 105 (8): 2773-8

PMID: 18287036 · PMCID: PMC2268535 · DOI:10.1073/pnas.0708281105

MeSH Terms (18)

Alkynes Aniline Compounds Animals Cell Proliferation Crystallography, X-Ray Dose-Response Relationship, Drug ErbB Receptors Female Isatin Mass Spectrometry Mice Mice, SCID Models, Molecular Molecular Structure Pyrimidines Receptor Protein-Tyrosine Kinases Structure-Activity Relationship Xenograft Model Antitumor Assays

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