Selection against pathogenic mtDNA mutations in a stem cell population leads to the loss of the 3243A-->G mutation in blood.

Rajasimha HK, Chinnery PF, Samuels DC
Am J Hum Genet. 2008 82 (2): 333-43

PMID: 18252214 · PMCID: PMC2427290 · DOI:10.1016/j.ajhg.2007.10.007

MeSH Terms (11)

Age Factors Computer Simulation DNA, Mitochondrial Hematopoietic Stem Cells Humans Mitochondrial Diseases Models, Biological Mutation RNA, Transfer, Amino Acyl RNA, Transfer, Lys Selection, Genetic

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