Trans-4-hydroxy-2-hexenal is a neurotoxic product of docosahexaenoic (22:6; n-3) acid oxidation.

Long EK, Murphy TC, Leiphon LJ, Watt J, Morrow JD, Milne GL, Howard JR, Picklo MJ
J Neurochem. 2008 105 (3): 714-24

PMID: 18194211 · DOI:10.1111/j.1471-4159.2007.05175.x

MeSH Terms (19)

Aldehydes Animals Brain Injury, Chronic Cells, Cultured Cerebral Cortex Docosahexaenoic Acids Dose-Response Relationship, Drug Female Free Radical Scavengers Glutathione Lipid Peroxidation Nerve Tissue Proteins Neurodegenerative Diseases Neurons Neurotoxins Oxidative Stress Rats Succinate-Semialdehyde Dehydrogenase Time Factors

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