Beta2 integrin mediates entry of a bacterial toxin into T lymphocytes.

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Cell Host Microbe. 2008 3 (1): 5-6

PMID: 18191787 · DOI:10.1016/j.chom.2007.12.004

Helicobacter pylori secretes a pore-forming toxin, VacA, that can cause numerous alterations in gastric epithelial cells and T lymphocytes. In this issue of Cell Host & Microbe, Sewald and colleagues report that beta2 integrin (CD18) mediates entry of VacA into human T cells. Downregulation of T cell responses by VacA may allow H. pylori to evade the adaptive immune response and establish persistent infection.

MeSH Terms (8)

Animals Bacterial Proteins CD18 Antigens Helicobacter pylori Humans Mice Receptors, Antigen, T-Cell T-Lymphocytes

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