Cooperativity in oxidation reactions catalyzed by cytochrome P450 1A2: highly cooperative pyrene hydroxylation and multiphasic kinetics of ligand binding.

Sohl CD, Isin EM, Eoff RL, Marsch GA, Stec DF, Guengerich FP
J Biol Chem. 2008 283 (11): 7293-308

PMID: 18187423 · DOI:10.1074/jbc.M709783200

MeSH Terms (15)

Animals Cytochrome P-450 CYP1A2 Dose-Response Relationship, Drug Humans Kinetics Ligands Magnetic Resonance Spectroscopy Models, Biological Models, Chemical Oxygen Protein Binding Pyrenes Rabbits Spectrometry, Fluorescence Substrate Specificity

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