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The hamster as a model for embryo implantation: insights into a multifaceted process.

Reese J, Wang H, Ding T, Paria BC
Semin Cell Dev Biol. 2008 19 (2): 194-203

PMID: 18178492 · PMCID: PMC2288742 · DOI:10.1016/j.semcdb.2007.11.001

Defects in preimplantation embryonic development, uterine receptivity, and implantation are the leading cause of infertility, pregnancy problems and birth defects. Significant progress has been made in our basic understanding of these processes using the mouse model, where implantation is ovarian estrogen-dependent in the presence of progesterone. However, an animal model where implantation is progesterone-dependent must also be studied to gain a full understanding of the embryo and uterine events that are required for implantation. In this regard, the hamster is a useful model and this review summarizes the information currently available regarding mechanisms involved in synchronous preimplantation embryo and uterine development for implantation in this species.

MeSH Terms (13)

Animals Cricetinae Cytokines Embryo Implantation Female Gene Expression Regulation, Developmental Intercellular Signaling Peptides and Proteins Models, Animal Morphogenesis Pregnancy Signal Transduction Uterus Vasodilation

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