pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis.

Gannon M, Ables ET, Crawford L, Lowe D, Offield MF, Magnuson MA, Wright CV
Dev Biol. 2008 314 (2): 406-17

PMID: 18155690 · PMCID: PMC2269701 · DOI:10.1016/j.ydbio.2007.10.038

MeSH Terms (15)

Animals beta-Galactosidase Blood Glucose Embryonic Development Gene Expression Regulation, Developmental Glucose Glucose Intolerance Glucose Tolerance Test Homeodomain Proteins Homeostasis Insulin-Secreting Cells Islets of Langerhans Mice Mice, Knockout Trans-Activators

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