Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure.

Minamishima YA, Moslehi J, Bardeesy N, Cullen D, Bronson RT, Kaelin WG
Blood. 2008 111 (6): 3236-44

PMID: 18096761 · PMCID: PMC2265460 · DOI:10.1182/blood-2007-10-117812

MeSH Terms (18)

Alleles Animals Cells, Cultured DNA-Binding Proteins Echocardiography Enzyme Activation Erythropoiesis Gene Expression Regulation, Enzymologic Heart Failure Hypoxia-Inducible Factor-Proline Dioxygenases Immediate-Early Proteins Mice Mice, Inbred C57BL Mice, Transgenic Phenotype Polycythemia Procollagen-Proline Dioxygenase RNA, Messenger

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