MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib.

Bean J, Brennan C, Shih JY, Riely G, Viale A, Wang L, Chitale D, Motoi N, Szoke J, Broderick S, Balak M, Chang WC, Yu CJ, Gazdar A, Pass H, Rusch V, Gerald W, Huang SF, Yang PC, Miller V, Ladanyi M, Yang CH, Pao W
Proc Natl Acad Sci U S A. 2007 104 (52): 20932-7

PMID: 18093943 · PMCID: PMC2409244 · DOI:10.1073/pnas.0710370104

MeSH Terms (18)

Adenocarcinoma Antineoplastic Agents Chromosomes, Human, Pair 7 Cohort Studies DNA Mutational Analysis Drug Resistance, Neoplasm ErbB Receptors Erlotinib Hydrochloride Gefitinib Gene Expression Regulation, Neoplastic Humans In Situ Hybridization, Fluorescence Lung Neoplasms Mutation Protein Kinase Inhibitors Proto-Oncogene Mas Proto-Oncogene Proteins c-met Quinazolines

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