Caffeine and miscarriage risk.

Savitz DA, Chan RL, Herring AH, Howards PP, Hartmann KE
Epidemiology. 2008 19 (1): 55-62

PMID: 18091004 · DOI:10.1097/EDE.0b013e31815c09b9

BACKGROUND - Coffee and caffeine have been inconsistently found to be associated with increased risk of clinical miscarriage-a potentially important association given the high prevalence of exposure.

METHODS - Women were recruited before or early in pregnancy and interviewed regarding sources of caffeine, including assessment of changes over the perinatal period. We identified 2407 clinically-recognized pregnancies resulting in 258 pregnancy losses. We examined the relationship of coffee and caffeine intake with clinically-recognized pregnancy loss prior to 20 weeks' completed gestation, using a discrete-time continuation ratio logistic survival model.

RESULTS - Coffee and caffeine consumption at all 3 time points were unrelated to total miscarriage risk and the risk of loss after the interview. Reported exposure at the time of the interview was associated with increased risk among those with losses before the interview.

CONCLUSIONS - There is little indication of possible harmful effects of caffeine on miscarriage risk within the range of coffee and caffeine consumption reported, with a suggested reporting bias among women with losses before the interview. The results may reflect exposure misclassification and unmeasured heterogeneity of pregnancy losses.

MeSH Terms (16)

Abortion, Spontaneous Adolescent Adult Caffeine Coffee Female Humans Interviews as Topic Middle Aged North Carolina Nutrition Surveys Odds Ratio Pregnancy Risk Factors Tennessee Texas

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