Occupation and breast cancer risk among Shanghai women in a population-based cohort study.

Ji BT, Blair A, Shu XO, Chow WH, Hauptmann M, Dosemeci M, Yang G, Lubin J, Gao YT, Rothman N, Zheng W
Am J Ind Med. 2008 51 (2): 100-10

PMID: 18067183 · PMCID: PMC2886981 · DOI:10.1002/ajim.20507

INTRODUCTION - A total of 74,942 female subjects were recruited in a population-based cohort study in Shanghai, China between 1997 and 2000. We examined the relationship between occupation and breast cancer risk.

METHODS - Cases were 586 women previously diagnosed with breast cancer at baseline and 438 women newly diagnosed with breast cancer during follow-up through December 2004. Eight controls were randomly selected for each case from cancer-free cohort members and frequency-matched to the cases by year of birth and age at diagnosis. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) of breast cancer risk associated with occupations, adjusting for established breast cancer risk factors.

RESULTS - In the prevalent breast cancer data analysis, increased risks of breast cancer were associated with technicians in engineering/agriculture/forestry (OR = 1.6, CI: 1.0-2.4), teaching personnel (OR = 1.5, CI:1.1-2.0), tailoring/sewing workers (OR = 1.6, CI:1.0-2.7), and examiners/measurers/testers (OR = 1.5, CI:1.1-2.1) among those who started the jobs at least 20 years ago. Among incident breast cancer cases, significantly increased risks were associated with medical/health care workers (OR = 1.4, CI:1.0-2.0), administrative clerical workers (OR = 1.5, CI:1.0-2.4), postal/telecommunication workers (OR = 2.2, CI:1.0-5.5), and odd-job workers (OR = 1.7, CI:1.1-2.8) among those who started the jobs at least 20 years ago. The excess risks were found in both prevalent and incident cases for postal/telecommunication workers and purchasing/marketing personnel, although ORs reached only marginal significance.

CONCLUSIONS - This study suggests that white-collar professionals and several production occupations may be associated with an increased risk of breast cancer.

MeSH Terms (17)

Adult Aged Breast Neoplasms Case-Control Studies China Female Health Surveys Humans Incidence Middle Aged Occupational Diseases Occupational Exposure Prevalence Risk Assessment Risk Factors Surveys and Questionnaires Women's Health

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