Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas.

Gao SP, Mark KG, Leslie K, Pao W, Motoi N, Gerald WL, Travis WD, Bornmann W, Veach D, Clarkson B, Bromberg JF
J Clin Invest. 2007 117 (12): 3846-56

PMID: 18060032 · PMCID: PMC2096430 · DOI:10.1172/JCI31871

MeSH Terms (21)

Adenocarcinoma Animals Cell Line, Tumor Cytokine Receptor gp130 Enzyme Inhibitors ErbB Receptors Female Gene Expression Regulation, Neoplastic Humans Interleukin-6 Janus Kinases Lung Neoplasms Mice Mice, Nude Mutation Neoplasm Transplantation Phosphorylation RNA, Small Interfering Signal Transduction STAT3 Transcription Factor Transcription, Genetic

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