An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission.

Shirey JK, Xiang Z, Orton D, Brady AE, Johnson KA, Williams R, Ayala JE, Rodriguez AL, Wess J, Weaver D, Niswender CM, Conn PJ
Nat Chem Biol. 2008 4 (1): 42-50

PMID: 18059262 · DOI:10.1038/nchembio.2007.55

MeSH Terms (25)

Allosteric Regulation Allosteric Site Animals Calcium CHO Cells Cricetinae Cricetulus Dose-Response Relationship, Drug Electrophysiology Hippocampus Humans Ligands Mice Mice, Knockout Molecular Structure Muscarinic Agonists Muscarinic Antagonists Protein Binding Pyramidal Cells Radioligand Assay Rats Receptor, Muscarinic M4 Small Molecule Libraries Structure-Activity Relationship Synaptic Transmission

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