Cytokine polymorphisms and gastric cancer risk: an evolving view.

Schneider BG, Camargo MC, Ryckman KK, Sicinschi LA, Piazuelo MB, Zabaleta J, Correa P, Williams SM
Cancer Biol Ther. 2008 7 (2): 157-62

PMID: 18059184 · DOI:10.4161/cbt.7.2.5270

More than 20 years after the identification of Helicobacter pylori as a human pathogen, gastric cancer continues to be a leading cause of cancer deaths worldwide. Genetic association studies have the potential for helping to identify those at greatest risk for developing gastric cancer subsequent to infection by H. pylori. IL1B promoter polymorphisms have been supported by several meta-analyses as being associated with gastric cancer risk. In this review, we discuss challenges in experimental design of gene association studies in gastric cancer, with attention to gene-environment interactions that may lead to inconsistency in findings across populations.

MeSH Terms (13)

Alleles Cytokines Gene Frequency Genetic Heterogeneity Genetic Predisposition to Disease Helicobacter Infections Helicobacter pylori Humans Linkage Disequilibrium Polymorphism, Genetic Promoter Regions, Genetic Risk Factors Stomach Neoplasms

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